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Most patients notice changes in appetite and food-related thoughts within the first few weeks of treatment, though the full effect on food noise typically develops over several weeks to months as doses are gradually increased to therapeutic levels
The association between depression and medication nonpersistence in new users of antidiabetic drugs
When it is time to stop using the medication, doctors may recommend gradually reducing the dose to help avoid withdrawal symptoms
Early GLP-1 development efforts were hindered by rapid degradation by dipeptidyl peptidase-4, short duration of action, and gastrointestinal intolerance at supraphysiologic exposure levels
who were overweight or had obesity and at least one other weight-related health problem, but not diabetes
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