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But that peripheral-only action means it does not suppress appetite, does not change energy expenditure through central pathways, and does not produce the dramatic caloric deficits that GLP-1 agonists like semaglutide or tirzepatide create

PMID: 41574827 Bioeng Transl Med Nanoalbumin-prodrug conjugates prepared via a thiolation-and-conjugation method improve cancer chemotherapy and immune checkpoint blockade therapy by promoting CD8+ T-cell infiltration

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[14] [35] Safety Profile Excellent preclinical safety: no toxicity at high doses, metabolized in liver, cleared by kidneys

Okamoto K, Aoki K