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273 , R1891R1899 (1997)
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Importantly, most researchers now believe the therapeutic effects of MSCs occur primarily through paracrine signaling , meaning the cells release biologically active substances that influence surrounding tissues rather than directly replacing cells
It was developed by modifying four amino acids in the native GHRH(1-29) sequence to increase resistance to enzymatic breakdown
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Increased iron absorption, lipid peroxidation, and the buildup of lipid peroxides, which results in cell death, are the hallmarks of the process
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