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They have been widely used for NADs delivery due to their excellent compatibility with cell membranes
Moreover, decreased TMAO urine excretion is associated with high salt dietary intake, increasing plasma TMAO concentration [82]
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Common side effects include: Gastrointestinal issues: Nausea (15-20%), vomiting (5-9%), diarrhea (8%), stomach pain (6-7%), and constipation (3-7%) Mild discomfort: Headache, dizziness, fatigue, bloating, gas, or heartburn Appetite changes: Some individuals report loss of appetite Most side effects are temporary and improve over time
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Stacking them adds redundant signaling, raises side-effect risk, and is not a pattern used in clinical trials
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