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Clurman, B
Doses may be lowered temporarily until symptoms resolve
And they were talking about the potential long-term consequences of that, both good and bad
and Yamanishi, T
Collectively, these clinical observations highlight that isoform-specific targeting is essential not only for efficacy but also for minimizing off-target side effects, emphasizing the need for early-stage ADME/PK and selectivity profiling in the development of novel dual PDE1B/PDE10A inhibitors
Chungfat N, Dixler I, Cohran V y cols
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