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Furthermore, subchronic ISF significantly decreased liver triacylglycerol (TG) content without altering weight of liver ( Figures 7D, E ) and significantly reduced the weight of mesenteric and perirenal white adipose tissues (WAT, Figures 7F, G ) and interscapular brown adipose tissues (I-BAT, Figure 7I ) but not the weight of epididymal WAT ( Figure 7H )
Glucagon receptor activation increases thermogenesis (heat production from burning calories), enhances fat oxidation (the breakdown of stored fat for energy), and boosts resting metabolic rate
For OCTN2, D139N is a variant potentially associated with SPCD that does localise correctly to the membrane, but does not impair transport activity in uptake assays 11
This means active ingredients reach where they are needed most, increasing their potency and results
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