So cycling MOTS-c is prudent practice rather than a pharmacologic requirement
Infection of the external ear and ear lobe (cellulitis) Neuralgia, pain caused by irritation of the nerves in the ear Pain from a sore throat or a problem with the jaw joints called temporomandibular joint disorders (TMJ) may be felt in the ear
While menstrual irregularities were not systematically reported as adverse events in published results, the substantial weight loss achieved (approximately 20.9% with the 15 mg dose) would be expected to influence reproductive hormone dynamics in premenopausal women based on established weight loss physiology
15,16 Jennings et al 15 demonstrated a significant decrease in weight (6.5 kg), HS Physicians Global Assessment (HS-PGA) (from 4 to 1), DLQI (from 24 to 14), and analgesic use (from daily to not daily) but no decrease in CRP (from 3 mg/dL) after eight weeks of treatment
[5] Badawy A, State O, Abdelgawad S
NICE guidelines (CG189) emphasise multicomponent weight management programmes that combine dietary modification, increased physical activity, and behavioural strategies