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Despite its advantages, its important to acknowledge GHK-Cus limitations when compared to traditional acne treatments in a research context: Limited Direct Evidence for Active Acne Vulgaris: While it has anti-inflammatory properties, there is currently limited direct clinical evidence specifically demonstrating GHK-Cu as a primary treatment for active acne breakouts (e.g., reducing papules, pustules, or cysts)

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Thus, we further explored whether GLP-1R is involved in CM by mediating microglial activation, including morphological changes and inflammation

Wang T, Hong JL, Gower EW, et al

Selenium deficiency has been associated with Th2 cell response, whereas higher selenium levels favour Th1 response (193)