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Cagrilintide is a long-acting amylin analogue that reduces appetite and slows gastric emptying, whilst retatrutide is a triple GLP-1, GIP, and glucagon receptor agonist designed to reduce appetite and increase energy expenditure
Gathering everything before starting prevents mid-process interruptions that leave vials exposed to air or temperature fluctuations
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REDEFINE 1 (Garvey et al., NEJM 2025) is the only Phase 3 trial of an amylin + incretin co-administered combination, pairing cagrilintide 2.4 mg with semaglutide 2.4 mg
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PMID: 22005198
