Metformin remains the first-line treatment for most people with newly diagnosed type 2 diabetes because it is safe, effective, and inexpensive
Cardiovascular outcome trials assess whether weight loss translates to reduced heart attacks, strokes, and cardiovascular deaths
Trevogrumab (REGN1033) is an antibody that binds to multiple forms of MSTN with high affinity and specificity, while avoiding closely related proteins such as GDF11 and activins, which also signal through activin type II receptors.[75] Another antibody that targets pro-MSTN and the latent form to inhibit the release of active MSTN is apitegromab (SRK-015).[76] The mature form of MSTN shares high similarity with other closely related TGF- family members, including GDF11, and activin receptors can bind a variety of ligands.[72] Therefore, inhibitors that target only mature MSTN or activin receptors may lead to undesirable off-target effects, as highlighted earlier
(It should be noted, however, that only male subjects were included in the first four trials.) But heres the catch: While scientists have currently found no alarm-sounding safety issues for AOD-9604, they also havent found evidence that the peptide actually helps you lose weight
Additional findings are due to be published in peer-reviewed journals and presented at the 86th annual American Diabetes Association Scientific Sessions, held in June 2026 in New Orleans, Louisiana, United States
Poison control centers report increase in calls related to drugs used for weight loss As the popularity of drugs used for weight loss has skyrocketed, so too have calls to poison control centers across the country, data shows