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Their current strategy is to contain near-term expenses while waiting for clearer long-term data and possible price competition (including generics or biosimilars)

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Excessive enhancement of ER-mitochondria calcium coupling may increase susceptibility to permeability transition, whereas excessive attenuation can impair antimicrobial signaling and lymphocyte activation, indicating that efficacy and clinical acceptability are likely to depend on cell type, disease stage and dosing regimen (162)

One activates two receptors

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