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And it seems like there's some degree of muscle sparing." Andrew Huberman This is broadly accurate on the weight loss figure but overstates the speed and simplifies the muscle data

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Interestingly, the aryl hydrocarbon receptor (AhR) of the tryptophan-kynurenine pathway serves as a critically important mediator between tryptophan metabolism, immune reactions, and tissue homeostasis (4143), and several kynurenine metabolites have been associated with fatigue (44, 45)

People who used aggressive weight loss medications or crash diets may face more significant laxity than those who lost weight steadily over a longer period

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Startups must recognize this trend and adapt their strategies accordingly