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Since it does not significantly affect postprandial (after meal) glucose control like short acting insulins do, it is often combined with them for patients requiring intensive glycemic control

Its unique mechanism may offer advantages for certain patients, especially those with IBS-C, but comprehensive comparisons with current therapies are pending further research

doi: 10.1016/j.plipres.2021.101094 21 FlynnC

Author response: We have altered the phrasing to read, Adult wildtype C57BL6/J mice were injected with TAM or matched dose (ml/kg) of vehicle (oil) for 5d. Reviewer 1 In regard to an issue raised by Reviewer 2 (below) I question whether the estrous cycle would need to be tracked

So the heart has to get from -80 mV to -65 mV to fire an action potential and beat

The peptide never entered pharmaceutical development pipelines, so the kind of Phase III data that exists for sleeping pills does not exist for DSIP