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The scientific rationale for the combination is derived from: (1) Ipamorelin pharmacology demonstrating GHSR-1a selective GH stimulation (Raun et al
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10.1007/s10787-025-01706-0 59
Semaglutide is the only one available in oral tablets
Ipamorelin is a selective growth hormone secretagogue that binds to the ghrelin receptor
Additionally, there was a decrease in the body mass index (BMI) and the patients reported that their menstrual cycles became more regular and that their hirsutism diminished (136)
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