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Statistical Analysis Each experiment was repeated three or more times with three experimental replicates, and the results were expressed as the mean SD

Metabolic analysis Oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) were measured with a 24-well XF Extracellular Flux Analyzer (Agilent Technologies) and Seahorse Wave Controller Software (Agilent Technologies), according to the manufacturers instructions

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