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Local ice application typically lasts 15-20 minutes per session, limited to prevent tissue damage from prolonged cold exposure

The damaged proteins accumulate at points, which erupts on the skin's surface as scars, broken capillaries, wrinkles, etc

British Society for Haemotology

Sessions typically last 45 to 90 minutes depending on the infusion

Increased toxicity of a pharmacologically active metabolite of irinotecan (SN38) has been described in patients suffering from Gilberts syndrome as UGT1A1 is the main enzyme responsible for the formation of the inactive SN38 glucuronide (Wasserman et al., 1997)

& Ratcliffe, J