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The triple action is designed to reduce appetite, slow gastric emptying, improve insulin response, and increase energy expenditure all at once

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GLP-1 promotes insulin secretion in a glucose-dependent manner, inhibits glucagon release, delays gastric emptying, and suppresses appetite, while GIP mainly enhances glucose-stimulated insulin secretion (Nauck and Meier, 2016)

Tissue-related signaling pathways

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Some argue this sustained elevation is less physiological and may carry more risk over time