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Mechanistically, in macrophages, GLP-1RAs directly ameliorate NF-B activation, thereby improving insulin resistance [132]

Furthermore, high glucose levels increase the formation of advanced glycation end products (AGEs) through the non-enzymatic reaction between reducing sugars and cellular proteins, lipids, or nucleic acids

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DISCLOSURES: The study authors disclosed having no relevant financial relationships.

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Diabetologia 48(9):17001713 Edwards K, Li X, Lingvay I (2023) Clinical and safety outcomes with GLP-1 receptor agonists and SGLT2 inhibitors in type 1 diabetes: a real-world study