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Heme oxygenase-1 gene promoter polymorphism is associated with reduced incidence of acute chest syndrome among children with sickle cell disease

A medication that causes significant local reactions can still be fully effective systemically

It is very clear from the STEP 1 extension trial and the SURPASS trial that you will generally go into a situation of weight regain if you stop these drugs

Gastrointestinal discomfort : Symptoms like bloating and indigestion may occur

In the earlier Phase 2 trial, the highest dose tested (45 mg) produced 14.7% weight loss at 36 weeks, suggesting that longer treatment and dose optimization may yield further improvements

Medical monitoring is also important during withdrawal, as stimulant cessation can lead to temporary fatigue and mood changes