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The funders had no role in the design, execution, interpretation, or writing of this study, and the authors maintain no personal or financial relationships that could potentially influence the work presented here

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Optimising glycaemic control to individualised HbA1c targets (typically 4853 mmol/mol) is the most important disease-modifying intervention to slow neuropathy progression

Even a modest weight loss of 5% has been shown to improve cardiometabolic risk factors, including reduced systolic blood pressure and plasma triglyceride concentration, and increased multi-organ insulin sensitivity and -cell function [6]

For optimal outcomes, a Tirzepatide treatment is often combined with nutritional guidance and healthy lifestyle habits, creating a supportive approach that promotes long-term success rather than short-term changes