It's derived from a protective protein found naturally in human gastric juice
In mouse embryonic fibroblasts, the elevation of CHAC1 protein expression following As III exposure is negatively regulated by the Tribbles homolog 3 (TRIB3), which limits CHAC1s pro-death potential (rd et al., 2016)
Proliferation (log 2 doublings, 5 days) of LDLR _KO and SCARB1 _KO cells expressing the indicated cDNAs or an empty vector (grey) under the indicated concentrations of ML162
Developmental mechanisms underlying the evolution of human cortical circuits
In vitro investigation of Dihexa routinely focuses on organotypic hippocampal slice cultures, primary rodent neuronal cultures, and human induced pluripotent stem cell (iPSC)-derived neurons
One study found copper-peptide complexes decreased inflammatory cytokines (IL-6 and TNF-alpha) produced by dermal fibroblasts