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Traditionally used as an anti-diabetic agent, Metformin was not only found to decrease HIF-1 expression of TMZ-resistant GBM cells in combination with TMZ but also, when used alone, was able to reverse hypoxia-induced genes by reducing the oxygen consumption rate (156)
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If children with autism have low levels of glutathione, could increasing their glutathione levels decrease their symptoms of autism
doi:10.3389/fnagi.2021.679711 Kawas LH, et al
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