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Over the next decade, gut proteins were isolated and found to have 50% sequence similarity to glucagon, and these proteins were termed glucagon-like peptides 1 and 2 (GLP-1 & 2)1

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More recently, the SUMMIT trial demonstrated that tirzepatide reduced the composite risk of cardiovascular death or worsening heart failure by 38% (HR = 0.62, 95% CI: 0.410.95) in patients with heart failure with preserved ejection fraction (HFpEF) and a BMI 30 kg/m 2 , 32% of whom also had type 2 diabetes