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Less toned look: The scale may drop, but without muscle, you may feel skinny fat instead of strong and lean
These effects are blunted by vagotomy or pharmacological GLP-1R blockade, and by genetic inactivation of GLP-1R signaling in whole body or selectively in vagal afferents
Reason being, dihydroberberine is naturally made in the human digestive tract as a berberine metabolite -- it's produced when the gut microbiome hydrogenates berberine so that it can absorb it
Risk reduction beyond glucose: The cardiovascular benefits appear to exceed what glucose control alone would provide
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Regarding hepatic effects, GLP-1 receptors are expressed at low levels in hepatocytes, though their functional significance remains debated
doi: 10.1177/1557988320966536 48 LandryFPrimosP
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