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Tirzepatide adds GIP activation to GLP1: In addition to GLP1, tirzepatide acts on another hormone called GIP, which enhances how the body handles nutrients and regulates appetite
Estimated Burden of Metabolic Dysfunction-Associated Steatotic Liver Disease in US Adults, 2020 to 2050
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The dose-escalation strategy (starting at 2 mg and increasing monthly) reduced the frequency and severity of nausea, a design borrowed from the SURPASS trials of tirzepatide [5]
The next hsCRP down 51% and blood pressure down 9.3mmHg stand out most, that's cardiovascular risk moving, not just the scale.
To calculate the stabilized propensity scores, multivariable logistic regression analysis was performed with the concomitant use of dulaglutide as the dependent variable and the following independent variables: age, sex, disease duration, BMI, HbA1c, AST, ALT, eGFR, dyslipidemia, dementia, GLP-1RA treatment modality (add-on, switch or reduce), initiation of GLP-1 RA treatment (outpatient or inpatient), number of oral antidiabetic agent classes, glucose-lowering agents (none, DPP-4 inhibitors, biguanides, SGLT-2 inhibitors, insulin), insulin dose
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