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In Phase 2 research, this pharmacological profile translated into the largest average weight reductions ever reported for a once-weekly peptide, catalyzing widespread interest among endocrinologists, obesity researchers, and metabolic-disease scientists

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Ischemia, inflammation, and other pathological stimuli lead to intracellular calcium overload, which activates a cascade of signaling pathways that promote the conversion of pro-MMP-9 into its active proteolytic form (148)

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