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This restores programmed cell death in cancer cell lines including SH-SY5Y neuroblastoma and U937 histiocytic lymphoma at 1-10 nanomolar concentrations, while paradoxically stimulating healthy NIH-3T3 fibroblast growth
Novo Nordisk selected 2.4 mg once weekly for phase 3, and that is the dose used in REDEFINE 1 and REDEFINE 2
5a) allows selective inhibition of CBS (raising cellular homocysteine levels and suppressing the production of H 2 S in a dose-dependent manner) over CSE
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Arch Endocrinol Metab (2021) 65:4217
Conclusion: Our findings suggest that PFOS and PFHxS have distinct effects on liver spheroids
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