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It also directly stimulates mast cell degranulation and promotes the release of pruritogens including histamine and prostaglandins
Given 40-60% nasal bioavailability compared to 80-95% for injection, equivalent nasal doses would be approximately 400-1000mcg to achieve similar systemic levels
Ros: a booster for chronic inflammation and tumor metastasis
GHK-Cu is released from proteins like collagen and SPARC through normal tissue turnover
It further shows that the levels of ATF4 and GSH in several human CML blast-crisis cell lines are inversely correlated with JMF4073 sensitivity, and the combinatory treatment of JMF4073 with GSH reducing agent leads to synthetic lethality in these CML blast-crisis lines
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