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Oxyntomodulin similarly reflects premature abandonment due to concerns about dual-receptor activity that have since been addressed by modern polypharmacologic approaches

10.2337/diabetes.47.4.544 130 SagerG.SmaglyukovaN.FuskevaagO-M

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Genetic Predispositions in GLP-1 Metabolism and Response Variability Emerging research shows that variants in GLP-1 receptor genes (such as GLP1R rs6923761), glucose-dependent insulinotropic peptide receptor genes (GIPR rs1800437), and metabolic pathways (FTO rs9939609, MC4R rs17782313) influence how individuals tolerate and respond to GLP-1 therapy

doi: 10.2337/db21-0103 114 GasbjergLSGabeMBNHartmannBChristensenMBKnopFKHolstJJet al

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