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(2008) demonstrated that systemic administration of IGF-1 LR3 to dystrophic mdx mice (a model of Duchenne muscular dystrophy) significantly reduced susceptibility to contraction-mediated damage in extensor digitorum longus, soleus, and diaphragm muscles

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Moreover IGF-1 was tested in patients with osteopenia/osteoporosis linked to anorexia nervosa and severe bone fractures with positive results utilising doses ranging from 30 g to 1 mg/kg/day for 29 months [274, 275]

It addresses multiple hallmarks of aging simultaneously

J Biol Chem (2010) 285:1407882

Third, and perhaps most relevant, it promotes fibroblast migration and collagen synthesis , the exact cellular processes needed to rebuild the damaged annulus fibrosus