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Increased NO activity can promote wakefulness and alertness in the short term (PubMed)

A., Gough, L

A 5mg vial reconstituted with 2ml yields 2.5mg/ml

5 , e1257 (2014)

NAD treatment may also help improve symptoms of anxiety, fatigue, and depression

The groups most likely to develop B12-related hair and skin changes are the same ones at risk for deficiency generally: vegans and vegetarians, adults over 50, people on long-term metformin or proton pump inhibitors, anyone who's had bariatric surgery, and people on GLP-1 protocols whose reduced appetite has significantly lowered their overall nutrient intake for an extended period