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Siebold and the other anonymous reviewer(s) for their contribution to the peer review of this work

The absorption technology needed to make oral GLP-1 medications work is proprietary and patented

supports once-weekly dosing

The secretagogue advantage is preserving the natural pulsatile pattern and avoiding exogenous GH's suppressive feedback, but this theoretical advantage has not translated into a demonstrated clinical superiority in head-to-head trials

Eli Lilly lawsuit (April 2025)

Estrogen helps support the health of muscles, tendons, ligaments, and joints, so as levels drop, connective tissues can become less resilient