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Tirzepatide is a prescription glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist indicated: As an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with a body mass index (BMI) 30 kg/m (obesity), or 27 kg/m (overweight) in the presence of at least one weight-related comorbidity (e.g., hypertension, type 2 diabetes, or dyslipidemia)
Available at: Bock-Marquette I, Saxena A, White MD, Dimaio JM, Srivastava D
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From Rat Studies to Human Extrapolation From rat studies, the remarkably consistent effective dose range of 0.0045 mg/lb to 0.0000045 mg/lb intraperitoneally (a 1000-fold range showing similar efficacy) worked across depression, anxiety, Parkinsons, stroke, schizophrenia, and seizure models
According to the data, it has the following pharmacokinetics: Time to max concentration: 24-72 hours Max availability: 89% Half life: approximately 7 days Time to steady state of current dose: 4-5 weeks With weekly dosing, the graph for Semaglutide is shown below