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Definition Research-use-only (RUO): A regulatory and labeling designation for laboratory reagents not intended for diagnostic, therapeutic, or human or veterinary use

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[1] [2] Women taking Rybelsus should be counselled about potential metabolic benefits, the importance of contraception if pregnancy is not desired, the need to discontinue at least 2 months before planned conception, and the importance of reporting any significant menstrual changes for appropriate clinical evaluation