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Rodent healing differs from human healing in various ways, and dose extrapolation involves assumptions that may not hold perfectly

[63] In 1998, a team of researchers at Novo Nordisk led by Lotte Bjerre Knudsen developed liraglutide, a GLP-1 receptor agonist that could be used to treat diabetes

Reduction in risk of nerve damage Diabetic neuropathy, characterized by damage to the nerves, is another complication of high blood sugar levels that can lead to pain, tingling, and numbness, primarily in the legs and feet

Only a small proportion (estimated 1-2%) of liraglutide circulates in the free (non-albumin bound) form, ready to diffuse into tissues and bind receptors

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In 2020 it was approved for the treatment of major depressive disorder (MDD) with acute suicidal ideation or behavior in adults