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However, whole-blood glutathione levels did not show significant changes

The apparent permeability coefficients (P app ) were calculated as described previously [40] with the following equation: where [C] A is the concentration difference of in the acceptor compartment at 24 h, [C] D is the concentration in the donor compartment at 0 h, V A is the volume of the acceptor compartment (0.9 ml), and A is the surface area available for permeability (0.33 cm 2 )

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Synthesis of ROS-sensitive polymers (P3) To a solution of ROS sensitive compound (2,2-(propane-2,2-diylbis(sulfanediyl))bis(ehan-1-ol)) (0.26 g, 1.35 mmol) in anhydrous DMF (5 ml), 1,2,4,5-cyclohexanetetracarboxylic dianhydride (0.31 g, 1.41 mmol) was quickly added into the solution

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