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Some individuals may experience no side effects at all, while others may find the initial weeks of treatment challenging

Higher NAD+ activates the sirtuin family of NAD+-dependent deacetylases, particularly SIRT1, which deacetylates PGC-1alpha (promoting mitochondrial biogenesis), FOXO transcription factors (enhancing stress resistance), and NF-kappaB (reducing inflammation)

Protein and magnesium deficiencies are also common

Cioce A, Cavani A, Cattani C, Scopelliti F