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Cent Nerv Syst Agents Med Chem 10:287297 Mahadevan D, Von Hoff DD (2007) Tumor-stroma interactions in pancreatic ductal adenocarcinoma

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Around D20 neurons were dissociated with Accutase and plated on matrigel-coated glass cover slips or in 35-mm culture wells with glass bottom

Antioxidants such as Vitamins A, C, and E provide radiation protection because radiation damage mimics oxidative stress associated with active oxygen toxicity.[] Tocopherol monoglucoside, a water-soluble Vitamin E derivative, has been found to be very effective in protecting DNA after oral or intraperitoneal administration of DNA against in vitro as well as gamma radiation.[] Melatonin (N-acetyl-5-methoxytryptamine), a pineal hormone that plays a role in the regulation of the neuroendocrine axis, is a highly effective free radical scavenger and antioxidant.[] When administered to mice before exposure to radiation, melatonin offered significant radiation protection, which is assessed by the frequency of chromosomal abnormalities in bone marrow cells, spermatogonia, spermatocytes and micronuclei.[] This study was performed to evaluate oxidative status, DNA damage and histopathological changes of radiation-induced lung injury