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The mechanism involves upregulation of VEGF expression a key growth factor in new blood vessel formation and activation of ERK1/2 signaling pathways that drive cell proliferation, migration, and angiogenesis

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[2] [5] [9] Spironolactone causes hyperkalemia and can cause life-threatening cardiac arrhythmias

Activating both receptors can improve insulin secretion, enhance fat metabolism and amplify appetite suppression

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