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High blood pressure is one of the most common consequences of ADPKD, and about half of individuals with ADPKD develop end-stage kidney disease by age 60 (NHGRI 2013)

(Arumugasaamy et al., 2019) found that both fluoxetine and sertraline slowed calcium oscillations in cardiomyocytes, inducing the increased secretion of troponin T and creatine kinase-MB, while also decreasing the secretion of N-terminal prohormone of brain natriuretic peptide (NT-proBNP), all three of which are key biomarkers of cardiac injury

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Organic toxins such as pesticides and solvents have also been associated with acute kidney injury and CKD (Pozzi 1985

A slight exertion comes with headaches and exhaustion, limiting a persons work capacity