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In clinical trials, people taking these medications often lose 15% to 20% of their body weight , which is greater than what was typically seen with earlier weight-loss medications

Semaglutide 2.4 mg was associated with mean weight losses of 14.9%-17.4% in individuals who are overweight or obese without type 2 diabetes in 68 weeks

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This is especially important for protecting lean muscle mass during the process

Notably, this was achieved in a shorter timeframe than the tirzepatide results, and with the weight loss curve still trending downward at the study endpoint suggesting the maximum effect had not yet been reached