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In heterogeneous tumor environments, achieving selective targeting of mutant p53 cells without damaging wild-type p53-dependent normal cells is a major challenge, mainly for the following reasons: some drugs targeting mutant p53 may also be toxic to wild-type p53 cells, and the complex tumor microenvironment may affect the efficacy of drugs
Receptor desensitization is less of a concern here than intuition might suggest
A comprehensive multivitamin, vitamin B12, vitamin D, and adequate protein supplementation are recommended with both medications
