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Paradoxically, reduction of intestinal GIP expression [93], GIPR antagonism [94] or genetic elimination of GIPR [95], also reduces food intake and promotes resistance to diet-induced obesity and weight loss in multiple species

This doesnt necessarily mean that HRT boosts semaglutides efficacy, the study authors proposed, but rather that not receiving HRT may weaken the post-menopausal bodys response to semaglutide

Beyond hepatic manifestations, MASLD is intrinsically linked to systemic metabolic disorder

A quick recap: how GLP-1 medications work GLP-1 receptor agonists mimic a natural hormone called glucagon-like peptide-1, which is released in the gut after eating

When they are prescribed GLP-1 medication, people need access to wraparound support, including dietetic advice, physical activity guidance and behavioural change support