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By linking endoplasmic reticulum health to the handling of oxidized glutathione, the study suggests that glutathione regulation may be a foundational part of keeping cellular protein production on track
The finding that younger people with COVID-19 also are glutathione deficient and have elevated oxidative stress and oxidant damage is really surprising, because we do not normally see these defects in younger age groups
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Diabetes Investig
This pathway, integral to cellular growth and survival, might also play a pivotal role in mediating the actions of IGF-1 on glucose uptake
Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways
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