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Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors

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doi: 10.3978/j.issn.2072-1439.2015.05.15 3 ZieglerRGAndersonWFGailMH

The sequence carries three methionine residues, two of them in the N-terminal extension, all oxidation-sensitive

Current pre-clinical data does not show tumor promotion at research doses, but this is an active area of inquiry