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a Phase II multicenter RCT as PL 14736 for mild-to-moderate ulcerative colitis (Pliva, completed but full results not published as a peer-reviewed paper)
Human obesity development did not establish statistically significant weight-loss efficacy in the largest reported placebo-controlled trial, and the available clinical record is insufficient to establish comprehensive safety, particularly across material forms, formulations, routes, and long-term exposure
Such complexity acts as a speed bump urging caution and regulation
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