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As supply catches up with demand and approvals widen their reach to new disease areas, these remarkable drugs stand poised to reshape healthcare, delivering a healthier future for individuals struggling with obesity and its devastating consequences.

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doi:10.1111/dom.13172

Moreover, these PD-L1 + cells, which also express high levels of cyclooxygenase-2 (COX2) and PGE2, exhibit immunosuppressive properties and can eliminate CD8 + T cells, thereby contributing to adaptive resistance to pembrolizumab treatment [185, 186]

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