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10.1074/jbc.C100401200 70 Motahari-RadH.SubiriA.SolerR.OcaaL.AlcaideJ.Rodrguez-CapitanJ.et al (2022)

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We suggest that the role of the kidney is crucial for the effect of SGLT-2i on the clinical outcomes not only because these drugs slow-down the time-dependent decline of kidney function and enhance the response to diuretics, but also because they attenuate the meal-related anti-natriuretic pressure (lowering postprandial hyperglycemia and hyperinsulinemia and preventing proximal sodium reabsorption), which would reduce the individual sensitivity to day-to-day variations in dietary sodium intake

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For example, you can: Send a coverage request letter to your employer