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Both groups achieved around 5% weight loss and saw similar reductions in liver fat and inflammation
Moreover, a GLP-1 analog, (Val(8))GLP-1-Glu-PAL, increased hippocampal neurogenesis and cell proliferation in obese mice fed a high-fat diet (Lennox et al., 2013)
As drug levels decline, effects gradually taper rather than stopping abruptly
The main concerns include additive gastrointestinal effects (nausea, vomiting, diarrhoea), cognitive side effects from topiramate (difficulty concentrating, memory problems), and potential for excessive weight loss
(PubMed) George JD, Kim E, Spain R, Bourdette D, Salinthone S
Medication options - Offering both oral and injectable formulations, as well as both semaglutide and tirzepatide, gives users some choice in how they approach treatment
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