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p21 is necessary but not sufficient to suppress ferroptosis We previously showed that expression of CDKN1A , encoding the CDK inhibitor p21, was necessary for wild-type p53 to suppress ferroptosis (Tarangelo et al, 2018)

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Although the recent developments show that they can provide antioxidants, growth factors, and regenerative agents in a better way, they are at an early phase of translation to clinical use